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Tesla P40 Passthrough GPU Disappears from the VM: “PCIe link to the device is down” on ESXi

My NVIDIA Tesla P40 in ESXi passthrough suddenly vanished from the VM: nvidia-smi could not talk to the driver and a VM reboot did not help. What the logs show, why only a host reboot fixes it, and how to make a homelab P40 stable (KB 418517).

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